Gene information
Official symbol PDGFA
Official full name platelet derived growth factor subunit A
Gene type protein-coding gene
Chromosome7p22.3
Alias symbolPDGF1; PDGF-A
Resources
Entrez Gene 5154
HGNC HGNC:8799
Ensembl ENSG00000197461
Vega OTTHUMG00000151412
UCSC uc003sis.4
GO terms: 113 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0005902 microvillus GO Cellular Components -2.78324946 11 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008406 gonad development GO Biological Processes -5.85435513 14 More
GO:0008584 male gonad development GO Biological Processes -2.74541064 14 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010464 regulation of mesenchymal cell proliferation GO Biological Processes -2.94884372 6 More
GO:0010544 negative regulation of platelet activation GO Biological Processes -8.56314160 7 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0014910 regulation of smooth muscle cell migration GO Biological Processes -16.4082106 27 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031952 regulation of protein autophosphorylation GO Biological Processes -4.76981182 6 More
GO:0031954 positive regulation of protein autophosphorylation GO Biological Processes -3.46447442 4 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032526 response to retinoic acid GO Biological Processes -5.75287026 10 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043588 skin development GO Biological Processes -3.97728448 25 More
GO:0045137 development of primary sexual characteristics GO Biological Processes -5.73912217 14 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046546 development of primary male sexual characteristics GO Biological Processes -2.71532895 14 More
GO:0046661 male sex differentiation GO Biological Processes -3.36897940 17 More
GO:0046982 protein heterodimerization activity GO Molecular Functions -2.81006698 12 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0048146 positive regulation of fibroblast proliferation GO Biological Processes -7.96091962 9 More
GO:0048286 lung alveolus development GO Biological Processes -3.35916365 8 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051055 negative regulation of lipid biosynthetic process GO Biological Processes -6.84973913 14 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051302 regulation of cell division GO Biological Processes -3.83250874 20 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051781 positive regulation of cell division GO Biological Processes -5.46648014 9 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0060693 regulation of branching involved in salivary gland morphogenesis GO Biological Processes -3.92643717 3 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0098858 actin-based cell projection GO Cellular Components -2.23189213 18 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1905330 regulation of morphogenesis of an epithelium GO Biological Processes -7.22524154 15 More
GO:2000027 regulation of animal organ morphogenesis GO Biological Processes -7.86416421 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 16 records
KEGG Description Category LogP Number of genes Detail
hsa01521 EGFR tyrosine kinase inhibitor resistance KEGG Pathway -6.02704244 9 More
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05214 Glioma KEGG Pathway -1.77153157 4 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05218 Melanoma KEGG Pathway -5.33688125 8 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
squalamine TTD view
sunitinib inhibitor MyCancerGenomeClinicalTrial view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
platelet-derived growth factor subunit A proteomics good predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Zhang Y et al. Cytokine. 2015
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